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Tags: cooling agent

Cooling Agent ws-23

Cooling Agent ws-23

Product Description The traditional coolants like menthol, peppermint oil and eucalyptus oil have the advantages of fast eruption and strong stimulation of cool feeling. But meanwhile they have the disadvantages of very strong characteristic smell, which is easy to volatilize at high temperature and contains bitter taste at high dosages. Now our cooling agent ws-23 can satisfy customer’s demands, it have strong cool feeling, non-peppermint, characteristic smell and no high volatility. Produc...

Cooling Agent ws-12

Cooling Agent ws-12

Product Description WS-12 is a cooling agent and potent TRPM8 agonist (EC50 = 193 nM). High-affinity TRPM8 (cold menthol receptor 1; CMR1) agonist. Has an EC50 value ~2’000 times lower than that of (-)-menthol (Prod. No. ALX-420-042). Advantages 1.There is a high cooling effect without other unpleasant feelings such as bitterness, burning, stinging or tingling sensations and can bring more stimulative, fresh and aromatic sensory to the entire mouth and throat. 2.Its melting point is f...

Cooling Agent ws-5

Cooling Agent ws-5

Product Description Cooling Agent WS-5 is the latest in a long line of cooling agents. Each have their own different ways of cooling different areas of the mouth and tongue and to different degrees. WS-5 is one of the strongest of all the cooling agents and is derived from menthol, although it is virtually odourless and has no taste. It provides a smooth and well rounded cooling effect and primarily affects the roof of the mouth and the back of the tongue. Advantages 1.Long-acting cooling a...

Cooling Agent ws-3

Cooling Agent ws-3

Product Description WS 3 is an agonist of TRPM8 receptor with EC50 value of 3.7 μM [1]. Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a Ca2+- and Na+-permeable ion channel and is activated by cooling agents and cold temperatures. TRPM8 belongs to TRP family and is expressed in sensory neurons. WS 3 is an agonist of TRPM8 receptor and a cooling agent. In HEK293 cells expressed recombinant mouse TRPM8, WS 3 (30 μM) increased [Ca2+]i. WS 3 exhibited potency with EC...

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