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Search keywords: cooling agent ws-3

Cooling Agent ws-3

Cooling Agent ws-3

Product Description WS 3 is an agonist of TRPM8 receptor with EC50 value of 3.7 μM [1]. Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a Ca2+- and Na+-permeable ion channel and is activated by cooling agents and cold temperatures. TRPM8 belongs to TRP family and is expressed in sensory neurons. WS 3 is an agonist of TRPM8 receptor and a cooling agent. In HEK293 cells expressed recombinant mouse TRPM8, WS 3 (30 μM) increased [Ca2+]i. WS 3 exhibited potency with EC...